Jonathan Grinstein,  —

Mouse Model for CLN6 Disease Shows Sex-specific Differences in Behavior, Lifespan, Study Finds

A mouse model representing CLN6 disease, a subtype of Batten disease, shows that females have different symptoms and a shorter lifespan than males, a study reports. This highlights the need for considering sex-specific differences in Batten disease progression when treating patients and developing therapeutic strategies. The study, “…

CLN8 Deficiency Disrupts Cell-Signaling Pathways, Study Reports

A type of Batten disease, called CLN8 disease, is associated with the failure of important cell- signaling molecules to properly interact and engage in critical signaling pathways, according to results of a recent study. The study, “Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels,”…