Mutations in CLN8 Block the Transport of Lysosomal Enzymes, Leading to Batten Disease, Study Shows

Genetic mutations in the CLN8 gene block the transport of lysosomal enzymes to lysosomes, the cellular compartments that digest and recycle different types of molecules, directly contributing to the development of Batten disease, a study has found. The study, “CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome…