Posts by: Marta Figueiredo

News

Naturally occurring canine models of several types of neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease, may aid in the development of new effective therapies for these conditions, according ... Read more

October 23, 2018October 23, 2018

Researchers ID 8 Potential Biomarkers of Disease Severity in Late Infantile Batten Disease

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Researchers have identified eight potential biomarkers of disease severity, progression and treatment response in children with late infantile Batten disease. Considering the nature of these biomarkers, the team suggested ... Read more

October 12, 2018October 12, 2018

CLN3 Protein Involved in Maintaining Water Balance, Batten Disease Model Shows

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CLN3, the protein lacking in the juvenile form of Batten disease (CLN3 disease), is involved in maintaining water balance, which is key for cell survival and growth, according to a recent study. ... Read more

October 2, 2018October 2, 2018

Researchers Explore Caspase-1 as Potential Therapeutic Target for CLN3 Disease

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Caspase-1 — an enzyme involved in several cellular processes, including inflammatory responses — is a potential therapeutic target to revert some of the features of CLN3 disease, the juvenile form of Batten ... Read more

July 31, 2018July 31, 2018

Discovery of Natural CLN7 Model in Type of Monkey May Help Advance Understanding of Disease

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Researchers have found a natural model of CLN7 disease, a rare form of Batten disease, in a type of monkey called a macaque, which may prove valuable in gaining ... Read more

July 10, 2018July 10, 2018

Common Disease Mechanisms Found Between Type of Batten Disease and Form of Adult Dementia

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Researchers have found common disease mechanisms between a type of Batten disease and a form of adult neurodegenerative disease. The study, “Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis,” ... Read more

June 22, 2018June 22, 2018

Newborn Screening Test Shows Promise for Detecting Late Infantile Batten Disease, Study Shows

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Researchers have developed a new newborn screening test that uses dried blood spots to more accurately diagnose late infantile Batten disease, along with six other lysosomal storage disorders. Findings were ... Read more

June 19, 2018June 19, 2018

Researchers Identify 5 New Mutations Linked to Form of Batten Disease

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Researchers have identified five new mutations in the CLN8 gene — the genetic factor behind CLN8 disease, one of a group of conditions known as NCLs, collectively called Batten disease. ... Read more

March 16, 2018March 16, 2018

New Mouse Model and Gene-Editing Tool May Help Advance CLN2 Research

News

A genetically modified mouse with increased levels of a specific enzyme in the brain, along with a new genetic tool, may help researchers further their understanding of late infantile neuronal ... Read more

Posts by: Marta Figueiredo

Marta Figueiredo

Canine Models of Batten Disease May Help to Develop New Therapeutic Approaches, Review Says

Researchers ID 8 Potential Biomarkers of Disease Severity in Late Infantile Batten Disease

CLN3 Protein Involved in Maintaining Water Balance, Batten Disease Model Shows

Researchers Explore Caspase-1 as Potential Therapeutic Target for CLN3 Disease

Discovery of Natural CLN7 Model in Type of Monkey May Help Advance Understanding of Disease

Common Disease Mechanisms Found Between Type of Batten Disease and Form of Adult Dementia

Newborn Screening Test Shows Promise for Detecting Late Infantile Batten Disease, Study Shows

Researchers Identify 5 New Mutations Linked to Form of Batten Disease

New Mouse Model and Gene-Editing Tool May Help Advance CLN2 Research

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